Published scoops - Science

6

What is knob into hole?

http://www.creativebiolabs.net

The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process, experts introduce a knob into the CH3 of one antibody and a corresponding hole into the CH3 of the other antibody via the alteration of AA respectively.

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Created by candyswift 2 days 16 hours ago – Made popular 1 day 23 hours ago
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7

Antibody&Antigen FAQ

http://www.creative-biolabs.com

What is antibody?
How many kinds of native antibodies exist in vivo?
How does antibody mature in vivo?
Is there any artificial antibody and what are their applications?
What are the applications of antibody in research?
What are the applications of antibody in clinic?
What is the difference between the applications of polyclonal antibody and monoclonal antibody?
What is antigen?
What kind of antigen is suitable for immunization to generate antibody?
How does antibody bind to its target antigen?
How to determine the affinity of certain antibody to antigen?

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Created by candyswift 5 days 9 hours ago – Made popular 4 days 6 hours ago
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6

Ecamsule inhibitor

http://www.bocsci.com

Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
Synonyms[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid; 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Ecamsule; Mexoryl SX; terephthalylidene dicamphor sulfonic acid; 92761-26-7; AC1O5SNJ; Ecamsule [USAN:USP:INN]; SCHEMBL119994; AKOS024464868;

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
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6

Cariprazine Inhibitor

http://www.bocsci.com

Cariprazine is an orally active D2/D3 dopamine receptor antagonist exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. It is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. It has also been used as a potential adjunct in treatment-resistant major depressive disorder.

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
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6

Gadobutrol inhibitor

http://www.bocsci.com

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framework and is neutral. It is a water-soluble, highly hydrophilic compound with a partition coefficient between n-butanol and buffer at pH 7.6 of ~ 0.006.

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
Category: Science   Tags:
6

6-Carboxytetramethylrhodamine

http://www.bocsci.com

6-carboxy derivatives of tetramethylrhodamine is one of the most convenient compounds of Xanthene fluorescent dye tetramethylrhodamine. 6-Carboxytetramethylrhodamine is a long-wavelength dye. Besides that, it also can be used for labeling of biomolecules, e.g., DNA, PNA, and peptides. Fluoresence: λex 543 nm, λem 575 nm in 0.1 M Tris pH 8.0; λex 540 nm, λem 565 nm in methanol; λex 555 nm, λem 580 nm; λex 541 nm, λem 568 nm in DMSO

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
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4

Loratadine Inhibitor

http://www.bocsci.com

Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.
Reference Reading
1.Effects of Prednisolone on the Pharmacokinetics of Loratadine after Oral and Intravenous Administration of Loratadine in Rats
2.Physicochemical characterization and dissolution enhancement of loratadine by solid dispersion technique

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Created by AdaBrown 6 weeks 10 hours ago – Made popular 5 weeks 5 days ago
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4

lamotrigine inhibitor

http://www.bocsci.com

Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Molecular Weight 256.09
Molecular Formula C9H7Cl2N5
Target Sodium Channel
Reference-Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child

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Created by AdaBrown 6 weeks 11 hours ago – Made popular 5 weeks 5 days ago
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3

L-NAME Inhibitor

http://www.bocsci.com

L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.

References:
1,Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum
2,Effect of L-arginine methyl ester (L-NAME) on hormonal profile and estrous cycle length in buffaloes (Bubalus bubalis)

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Created by AdaBrown 6 weeks 11 hours ago – Made popular 5 weeks 5 days ago
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3

Ghk-cu peptides

http://www.creative-peptides.com

Copper peptide is a naturally occurring copper complex of a glycyl-L-histidyl-L-lysine peptide. It can promote activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts.

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Created by anniegggg 7 weeks 5 days ago – Made popular 7 weeks 3 days ago
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