Published scoops - Science

3

Lanreotide APIs

http://www.creative-peptides.com

Lanreotide is a synthetic analogue of somatostatin, a naturally occurring inhibitory hormone which blocks the release of several other hormones, including growth hormone, thyroid-stimulating hormone (TSH), insulin and glucagon. Lanreotide binds to the same receptors as somatostatin, with higher affinity to peripheral receptors, and has similar activity.

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Created by AdaBrown 3 weeks 6 days ago – Made popular 3 weeks 4 days ago
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3

Liraglutide APIs

http://www.creative-peptides.com

Liraglutide (NN2211) is a long-acting glucagon-like peptide-1 receptor agonist, binding to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion.
Marketed under the brand name Victoza, liraglutide is an injectable drug developed for the treatment of type 2 diabetes.

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Created by AdaBrown 3 weeks 6 days ago – Made popular 3 weeks 4 days ago
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3

Oxytocin peptide

http://www.creative-peptides.com

Sequence CYIQNCPLG-NH2
M.W/Mr. 1007.20
Molecular Formula C43H66N12O12S2Length9
Creative Peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products.

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Created by AdaBrown 3 weeks 6 days ago – Made popular 3 weeks 4 days ago
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3

p-Menthane-3,8-diol

http://www.bocsci.com

P-Menthane-3,8-diol, also called PARA-MENTHANE-3,8-DIOL, PMD, 1-(2-Hydroxy-4-methylcyclohexyl)-1-methylethanol,ect. Found in small quantities in the essential oil from the leaves of Corymbia citriodora, formerly known as Eucalyptus citriodora.It smells similar to menthol and has a cooling feel

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Created by AdaBrown 4 weeks 6 days ago – Made popular 4 weeks 4 days ago
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3

NB-4 Myeloma Cells

http://www.creative-bioarray.com

The NB-4 cell line was derived from the marrow of a patient with acute promyelocytic leukemia (APL; M3 in the FAB nomenclature) in second relapse in 1989.
Recommended MediumRPMI-1640 medium supplemented with L-glutamine and 10% fetal bovine serum.

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Created by AdaBrown 7 weeks 3 days ago – Made popular 7 weeks 1 day ago
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4

WAY-252623 Inhibitor

http://www.bocsci.com

WAY-252623 (LXR-623) is a highly selective and orally bioavailable synthetic modulator of LXR, which can reduces total serum cholesterol and LDL cholesterol and inhibits lesion growth in models of atherosclerosis. IC50 values= 24 and 179 nM (for LXRβ and LXRα, respectively)

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Created by AdaBrown 8 weeks 2 days ago – Made popular 8 weeks 7 hours ago
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4

PIK-75 inhibitor

http://www.bocsci.com

PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK-75, administered at 50 mg/kg, inhibited the growth of HeLa cell xenografts in mice models.

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Created by AdaBrown 8 weeks 2 days ago – Made popular 8 weeks 7 hours ago
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4

Quizartinib inhibitor

http://www.bocsci.com

Quizartinib is an orally available small molecule with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis.

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Created by AdaBrown 8 weeks 2 days ago – Made popular 8 weeks 7 hours ago
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4

Cyt387 Inhibitor

http://www.bocsci.com

Cyt387, also called Momelotinib, under the IUPAC name N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide, is an ATP competitive inhibitor of JAK1 (IC50 = 11 nM) and JAK2 (IC50 = 18 nM) with potential antineoplastic activity, which may result result in the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.

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Created by AdaBrown 8 weeks 2 days ago – Made popular 8 weeks 1 day ago
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4

GW3965 inhibitor

http://www.bocsci.com

GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay

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Created by AdaBrown 8 weeks 2 days ago – Made popular 8 weeks 1 day ago
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