Published scoops - Science

4

antibody affinity

http://www.creative-biolabs.com

Affinity maturation is the process to improve antibody affinity for an antigen. In vivo, natural affinity maturation by the immune system takes place by somatic hypermutation and clonal selection. In vitro, in the laboratory affinity maturation, can be obtained by mutation and selection.

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Created by candyswift 19 hours 10 min ago – Made popular 1 hour 6 min ago
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4

humanized monoclonal antibodies

http://www.creative-biolabs.com

Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system. Since the development of the hybridoma technology, a large number of rodent monoclonal antibodies with specificity for antigens of therapeutic interest have been generated and characterized.

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Created by candyswift 19 hours 9 min ago – Made popular 1 hour 6 min ago
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4

cell proliferation assay

http://www.creative-biolabs.com

SIAT® DC-T cell proliferation assay uses Flow Cytometry to detect T cell proliferation after co-culture with loaded DCs, which is extremely sensitive and accurate. Specifically, T cells are labeled with 5,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) dye.

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Created by candyswift 19 hours 11 min ago – Made popular 1 hour 6 min ago
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4

rabbit antibody

http://www.creative-biolabs.com

The rabbit antibody repertoire is an exceptional source for both polyclonal antibodies and monoclonal antibodies that combine high specificity with high avidity and affinity. In addition, rabbits, which belong to the order Lagomorpha (lagomorphs), are evolutionarily distant from mice and rats, which belong to the order Rodentia (rodents).

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Created by candyswift 19 hours 12 min ago – Made popular 1 hour 6 min ago
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4

human monoclonal antibodies

http://www.creative-biolabs.com

Creative Biolabs offers an innovative custom service to produce native human monoclonal antibodies through our unique Native™ Antibody Discovery Platform.For technical reasons, current in vitro antibody display methods cannot provide human antibodies with naturally paired heavy chain and light chain. This could potentially lead to the generation of antibody molecules that have suboptimal solubility or other biophysical characteristics.

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Created by candyswift 19 hours 13 min ago – Made popular 1 hour 6 min ago
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4

camel antibodies

http://www.creative-biolabs.com

Camelid, especially camel and llama, is a kind of novel source for the research and development of antibody. Compared with other species, camelid members are the only mammals who can produce not only the conventional antibodies composed of heavy chains and light chains, but also novel antibodies only with heavy chains.

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Created by candyswift 19 hours 21 min ago – Made popular 1 hour 7 min ago
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6

What is knob into hole?

http://www.creativebiolabs.net

The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process, experts introduce a knob into the CH3 of one antibody and a corresponding hole into the CH3 of the other antibody via the alteration of AA respectively.

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Created by candyswift 2 days 20 hours ago – Made popular 2 days 2 hours ago
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7

Antibody&Antigen FAQ

http://www.creative-biolabs.com

What is antibody?
How many kinds of native antibodies exist in vivo?
How does antibody mature in vivo?
Is there any artificial antibody and what are their applications?
What are the applications of antibody in research?
What are the applications of antibody in clinic?
What is the difference between the applications of polyclonal antibody and monoclonal antibody?
What is antigen?
What kind of antigen is suitable for immunization to generate antibody?
How does antibody bind to its target antigen?
How to determine the affinity of certain antibody to antigen?

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Created by candyswift 5 days 13 hours ago – Made popular 4 days 9 hours ago
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6

Ecamsule inhibitor

http://www.bocsci.com

Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
Synonyms[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid; 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Ecamsule; Mexoryl SX; terephthalylidene dicamphor sulfonic acid; 92761-26-7; AC1O5SNJ; Ecamsule [USAN:USP:INN]; SCHEMBL119994; AKOS024464868;

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
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6

Cariprazine Inhibitor

http://www.bocsci.com

Cariprazine is an orally active D2/D3 dopamine receptor antagonist exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. It is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. It has also been used as a potential adjunct in treatment-resistant major depressive disorder.

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Created by AdaBrown 1 week 2 days ago – Made popular 1 week 2 days ago
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