6

Ethyl 4-aminobenzoate

http://www.bocsci.com

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops
Reference reading:
1. Assembling and de-assembling micelles: competitive interactions of cyclodextrins and drugs with Pluronics
In this work, we solubilised the local anaesthetic lidocaine or benzocaine into F127 micelles at varying concentrations. A simple phase diagram of F127 in the presence of lidocaine shows regions of existence of either a sol or a gel state (Fig. 7).

Read more »
Created by AdaBrown 1 year 5 weeks ago – Made popular 1 year 5 weeks ago
Category: Science   Tags:
6

Vorinostat Inhibitor

http://www.bocsci.com

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM.
Reference Reading
1. Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor
Marian Iwamoto • Evan J. Friedman •Punam Sandhu • Nancy G. B. Agrawal. Cancer Chemother Pharmacol (2013) 72:493–508
Vorinostat is an HDAC inhibitor currently marketed in the United States and other countries for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) who have progressive disease, persistent, or recurrent disease following two systemic therapies. Vorinostat inhibits the enzymatic activity of Class I (HDAC1, HDAC2, HDAC3) and Class II (HDAC6) HDACs at nanomolar concentrations (IC50<86 nM). A clinical study of vorinostat in patients with stage Ib and higher CTCL, who had failed to two systemic therapies (one containing bexarotene), demonstrated a 30 % overall objective response. An additional study in refractory CTCL patients demonstrated a similar response rate of 31 %.

Read more »
Created by AdaBrown 1 year 5 weeks ago – Made popular 1 year 5 weeks ago
Category: Science   Tags:
6

Misoprostol and Impurities

http://www.bocsci.com

Misoprostol is a cytoprotective prostaglandin PGE1 analogue.

Reference:
1.Second Trimester Medical Termination of Pregnancy with Combined Intracervical and Intravaginal Misoprostol: Comparative Analysis with Intravaginal Misoprostol—A Pilot Study
The authors in this study selected a dose of 600 lg for intravaginal misoprostol for the control group, as this is the dose commonly employed for second trimester termination of pregnancy

Read more »
Created by AdaBrown 1 year 5 weeks ago – Made popular 1 year 5 weeks ago
Category: Science   Tags:
6

Alfuzosin HCl inhibitor

http://www.bocsci.com

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
Molecular Weight 425.91
Molecular Formula C19H28ClN5O4
Adrenergic Receptor
The aim of the present work was to develop simple and sensitive kinetic spectrophotometric methods for the determination of alfuzosin HCl in bulk and in its pharmaceutical preparations using alkaline potassium permanganate as an oxidizing agent.

Read more »
Created by AdaBrown 1 year 5 weeks ago – Made popular 1 year 5 weeks ago
Category: Science   Tags:
6

antibody affinity

http://www.creative-biolabs.com

Affinity maturation is the process to improve antibody affinity for an antigen. In vivo, natural affinity maturation by the immune system takes place by somatic hypermutation and clonal selection. In vitro, in the laboratory affinity maturation, can be obtained by mutation and selection.

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:
5

humanized monoclonal antibodies

http://www.creative-biolabs.com

Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system. Since the development of the hybridoma technology, a large number of rodent monoclonal antibodies with specificity for antigens of therapeutic interest have been generated and characterized.

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:
6

cell proliferation assay

http://www.creative-biolabs.com

SIAT® DC-T cell proliferation assay uses Flow Cytometry to detect T cell proliferation after co-culture with loaded DCs, which is extremely sensitive and accurate. Specifically, T cells are labeled with 5,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) dye.

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:
6

rabbit antibody

http://www.creative-biolabs.com

The rabbit antibody repertoire is an exceptional source for both polyclonal antibodies and monoclonal antibodies that combine high specificity with high avidity and affinity. In addition, rabbits, which belong to the order Lagomorpha (lagomorphs), are evolutionarily distant from mice and rats, which belong to the order Rodentia (rodents).

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:
6

human monoclonal antibodies

http://www.creative-biolabs.com

Creative Biolabs offers an innovative custom service to produce native human monoclonal antibodies through our unique Native™ Antibody Discovery Platform.For technical reasons, current in vitro antibody display methods cannot provide human antibodies with naturally paired heavy chain and light chain. This could potentially lead to the generation of antibody molecules that have suboptimal solubility or other biophysical characteristics.

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:
5

camel antibodies

http://www.creative-biolabs.com

Camelid, especially camel and llama, is a kind of novel source for the research and development of antibody. Compared with other species, camelid members are the only mammals who can produce not only the conventional antibodies composed of heavy chains and light chains, but also novel antibodies only with heavy chains.

Read more »
Created by candyswift 1 year 7 weeks ago – Made popular 1 year 7 weeks ago
Category: Science   Tags:

User login

EzySpot is a news/social bookmarking site.

Monetize Your Website
TMZ VPS

Syndicate

Syndicate content