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Admission in IB School Mumbai | International School

http://mlsi.in

The MLSI subscribes to all inclusive and non-discriminatory admission practices.For detail international school admission procedure visit or click MLSI. MLSI is an inclusive school, where all students have a right to equal opportunities in accessing the curriculum. The school is committed to providing quality and appropriate education to all its students, ensuring that they may access the curricula in accordance with their chronological age and with appropriate differentiation to match their abilities and needs.

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Created by MarthaRose 46 weeks 6 days ago – Made popular 46 weeks 6 days ago
Category: Science   Tags:
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Antibody&Antigen FAQ

http://www.creative-biolabs.com

What is antibody?
How many kinds of native antibodies exist in vivo?
How does antibody mature in vivo?
Is there any artificial antibody and what are their applications?
What are the applications of antibody in research?
What are the applications of antibody in clinic?
What is the difference between the applications of polyclonal antibody and monoclonal antibody?
What is antigen?
What kind of antigen is suitable for immunization to generate antibody?
How does antibody bind to its target antigen?
How to determine the affinity of certain antibody to antigen?

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Created by candyswift 32 weeks 2 days ago – Made popular 32 weeks 1 day ago
Category: Science   Tags:
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What is knob into hole?

http://www.creativebiolabs.net

The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process, experts introduce a knob into the CH3 of one antibody and a corresponding hole into the CH3 of the other antibody via the alteration of AA respectively.

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Created by candyswift 32 weeks 1 hour ago – Made popular 31 weeks 6 days ago
Category: Science   Tags:
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Ecamsule inhibitor

http://www.bocsci.com

Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
Synonyms[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid; 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Ecamsule; Mexoryl SX; terephthalylidene dicamphor sulfonic acid; 92761-26-7; AC1O5SNJ; Ecamsule [USAN:USP:INN]; SCHEMBL119994; AKOS024464868;

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Created by AdaBrown 32 weeks 6 days ago – Made popular 32 weeks 6 days ago
Category: Science   Tags:
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Cariprazine Inhibitor

http://www.bocsci.com

Cariprazine is an orally active D2/D3 dopamine receptor antagonist exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. It is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. It has also been used as a potential adjunct in treatment-resistant major depressive disorder.

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Created by AdaBrown 32 weeks 6 days ago – Made popular 32 weeks 6 days ago
Category: Science   Tags:
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Gadobutrol inhibitor

http://www.bocsci.com

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framework and is neutral. It is a water-soluble, highly hydrophilic compound with a partition coefficient between n-butanol and buffer at pH 7.6 of ~ 0.006.

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Created by AdaBrown 32 weeks 6 days ago – Made popular 32 weeks 6 days ago
Category: Science   Tags:
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6-Carboxytetramethylrhodamine

http://www.bocsci.com

6-carboxy derivatives of tetramethylrhodamine is one of the most convenient compounds of Xanthene fluorescent dye tetramethylrhodamine. 6-Carboxytetramethylrhodamine is a long-wavelength dye. Besides that, it also can be used for labeling of biomolecules, e.g., DNA, PNA, and peptides. Fluoresence: λex 543 nm, λem 575 nm in 0.1 M Tris pH 8.0; λex 540 nm, λem 565 nm in methanol; λex 555 nm, λem 580 nm; λex 541 nm, λem 568 nm in DMSO

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Created by AdaBrown 32 weeks 6 days ago – Made popular 32 weeks 6 days ago
Category: Science   Tags:
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Simvastatin Inhibitor

http://www.bocsci.com

Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .
TargetsHMG-CoA Reductase (HMGCR)
Reference Reading
1. Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment
Although we did not detect any ATV metabolites in surface water, interestingly we did detect the presence of the main and active metabolite of the statin prodrug simvastatin (SV); simvastatin hydroxy carboxylic acid (SVA) in four of the surface water and sediments collected from Oslofjord.The surface water samples collected contained SVA at concentrations > LODand up to 66 ng L-1, whilst two sediment samples contained low ng g-1 (dw) concentrations of SVA also. No effluent concentrations of SVA were determined; however, we have previously reported the occurrence of SV at low ng L-1 in VEAS WwTW effluent suggesting from these preliminary data that effluent concentrations of SVA would indeed be higher.

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Created by AdaBrown 29 weeks 4 days ago – Made popular 29 weeks 4 days ago
Category: Science   Tags:
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Ethyl 4-aminobenzoate

http://www.bocsci.com

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops
Reference reading:
1. Assembling and de-assembling micelles: competitive interactions of cyclodextrins and drugs with Pluronics
In this work, we solubilised the local anaesthetic lidocaine or benzocaine into F127 micelles at varying concentrations. A simple phase diagram of F127 in the presence of lidocaine shows regions of existence of either a sol or a gel state (Fig. 7).

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Created by AdaBrown 29 weeks 4 days ago – Made popular 29 weeks 4 days ago
Category: Science   Tags:
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Vorinostat Inhibitor

http://www.bocsci.com

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM.
Reference Reading
1. Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor
Marian Iwamoto • Evan J. Friedman •Punam Sandhu • Nancy G. B. Agrawal. Cancer Chemother Pharmacol (2013) 72:493–508
Vorinostat is an HDAC inhibitor currently marketed in the United States and other countries for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) who have progressive disease, persistent, or recurrent disease following two systemic therapies. Vorinostat inhibits the enzymatic activity of Class I (HDAC1, HDAC2, HDAC3) and Class II (HDAC6) HDACs at nanomolar concentrations (IC50<86 nM). A clinical study of vorinostat in patients with stage Ib and higher CTCL, who had failed to two systemic therapies (one containing bexarotene), demonstrated a 30 % overall objective response. An additional study in refractory CTCL patients demonstrated a similar response rate of 31 %.

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Created by AdaBrown 29 weeks 4 days ago – Made popular 29 weeks 4 days ago
Category: Science   Tags:

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