Fragile X Syndrome (FXS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033 thelansis.com

Fragile X syndrome (FXS) is a rare genetic disorder with a wide range of symptoms, affecting both males and females. In males, it typically manifests in childhood with delayed development, varying degrees of intellectual deficits, and potential behavioral issues. These behaviors can range from mild anxiety and mood swings to more severe problems like aggression and autism-like traits such as hand flapping and gaze avoidance. In contrast, females usually experience milder intellectual and behavioral challenges, often marked by shyness and social anxiety. The underlying cause of FXS is the silencing of the FMR1 gene on the X chromosome, primarily due to the expansion and methylation of CGG trinucleotide repeats in its 5′-untranslated region. This gene codes for the FMRP protein, which regulates protein synthesis in neurons, impacting synaptic plasticity in various brain regions, including the hippocampus. Physical features associated with FXS include a high forehead, large ears, hyperextensible finger joints, flat feet with pronation, and enlarged testes in adolescent and adult males (macroorchidism). However, these physical traits can be mild or absent, making diagnosis challenging based solely on appearance. Diagnosis relies on FMR1 DNA testing and should be considered for individuals with intellectual deficits or autism. FXS can be distinguished from other X-linked intellectual disorders, Sotos syndrome, microdeletion syndromes, fetal alcohol syndrome, or idiopathic autism through appropriate testing. Management of FXS is multidisciplinary and symptom-focused. Therapies such as speech, physical, and sensory integration therapy, personalized educational plans, and behavioral interventions are commonly used. Medications like stimulants, selective serotonin reuptake inhibitors (SSRIs), and atypical antipsychotics may also be prescribed based on individual needs. Life expectancy in individuals with FXS is typically normal, but the prognosis varies based on symptom severity. Some may achieve independent living with limited support, while those with more severe intellectual and behavioral challenges require ongoing care.
• Although FXS is rare, affecting about 1 in 7,000 males and 1 in 11,000 females, it’s important to consider genetic testing for individuals with intellectual deficits or autism to ensure early diagnosis and appropriate management.

Thelansis’s “Fragile X Syndrome (FXS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033″ covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Fragile X Syndrome (FXS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Fragile X Syndrome (FXS) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.
Fragile X Syndrome (FXS) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.
Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.
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